The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyIntravenous200 mg/kg of body weightImmediately after injury
Model: Lateral cortical impact traumatic brain injury caused by a free-falling object
Ceftriaxone attenuated injury-induced cerebral oedema and cognitive deficits, significantly reduced IL-1beta, interferon-gamma and TNF-alpha, and upregulated glutamate transporter-1 expression after traumatic brain injury.
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