THERAPY DOSSIER · th-1c08e0edbb00

Ceftriaxone

Drug · Bacterial penicillin-binding protein inhibitor

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Bacterial penicillin-binding protein inhibitor
Target: Penicillin-binding protein
Injury models: TBI
Reported indication: Bacterial infections (meningitis, pneumonia, sepsis, gonorrhoea, surgical prophylaxis); 3rd-generation cephalosporin, approved 1984
First approval: 1984
Development stage: Approved antibiotic; neuroprotection/acute-brain-injury use investigational
ChEMBL record: CHEMBL161 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Ceftriaxon; Ceftriaxona; Ceftriaxone
Note: Not recorded

Clinical trials 7

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06819592 ↗Injury indicationPHASE3recruiting

Trial title not recorded

All-cause Mortality · Acute Brain Injury · Ventilation, Mechanical · Intensive Care Medicine

Enrolment: 3300 · Results not recorded

NCT07450404 ↗Injury indicationPhase not recordednot yet recruiting

Trial title not recorded

Early Ventilator Associated Pneumonia · Acute Brain Injuries

Enrolment: 60 · Results not recorded

NCT02224040 ↗PHASE4unknown

Trial title not recorded

Typhoid Fever

Enrolment: 120 · Results not recorded

NCT05654896 ↗PHASE3unknown

Trial title not recorded

Antibiotic Prophylaxis

Enrolment: 158 · Results not recorded

NCT00512616 ↗PHASE2withdrawn

Trial title not recorded

Bipolar Disorder

Enrolment: 0 · Results not recorded

NCT03895567 ↗PHASE1suspended

Trial title not recorded

Healthy

Enrolment: 37 · Results not recorded

NCT02800785 ↗NAcompleted

Trial title not recorded

Appendicitis

Enrolment: 1552 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22710775 ↗2012Reported benefit

The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury.

RatTBIControlled cortical impactSprague-DawleyIntravenous200 mg/kg of body weightImmediately after injury

Model: Lateral cortical impact traumatic brain injury caused by a free-falling object

Ceftriaxone attenuated injury-induced cerebral oedema and cognitive deficits, significantly reduced IL-1beta, interferon-gamma and TNF-alpha, and upregulated glutamate transporter-1 expression after traumatic brain injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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