Calcitonin gene-related peptide ameliorates hyperoxia-induced lung injury in neonatal rats.
RatOtherSprague-DawleyConcurrent with hyperoxia exposure
Model: Hyperoxia-induced neonatal lung injury (95% oxygen for 14 days)
Survival improved from 73% under hyperoxia to 84% with CGRP (93% in normoxia). CGRP alleviated hyperoxia-induced histomorphological change, reduced bronchoalveolar lavage leukocyte counts and total protein, restored superoxide dismutase activity, lowered malondialdehyde, and reduced TNF-alpha mRNA…
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