Erythropoietin enhances the regeneration of traumatized tissue after combined muscle-nerve injury.
RatCrushPeripheral-nerve crushWistarMalen = 84 rats total; n=7 per group per time pointIntraperitoneal5,000 IU/kg body weightOn induction of the trauma
Model: Combined left soleus muscle crush (instrumented clamp over full muscle length) with ipsilateral sciatic nerve crush or sham manipulation
Combined muscle and nerve injury caused significant loss of muscle strength that recovered incompletely by 42 days. EPO treated rats had greater muscle strength at days 7 and 42, less pain, improved nerve conduction velocity and increased bromodeoxyuridine positive proliferating cells.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.