Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model.
RatCrushLimb / muscle crushIntravenous100, 200 and 500 micromol/kgImmediately before reperfusion (after 5 h compression)
Model: Crush syndrome: bilateral hind limb compression with rubber tourniquets for 5 h followed by up to 6 h reperfusion
Muscle nitrite was reduced during ischaemia-reperfusion in crush syndrome. Nitrite restored muscle nitrite and nitric oxide bioavailability, lowered potassium, lactate dehydrogenase and creatine phosphokinase, reduced plasma interleukin-6 and myeloperoxidase in muscle and lung, and dose-dependently…
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