PRECLINICAL PUBLICATION · 2012

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Fibroblast growth factor-2 (FGF2) encapsulated in poly(lactide-co-glycolide) nanoparticles embedded in a hyaluronan and methylcellulose (HAMC) hydrogel

PMID 22688984 ↗2012Reported benefit

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure.

RatIschaemia-reperfusionRenalSprague-DawleyMaleIntrarenal injectionAfter bilateral ischemia

Model: Bilateral renal ischemia causing acute renal failure

Recombinant FGF-2 reduced iNOS, haem oxygenase-1, erythropoietin, renin, kallikrein and bradykinin B2 receptor levels and reduced renal damage, while COX-2 rose. FGF-2 receptor downregulation with antisense produced the opposite pattern, indicating differential regulation of metabolic pathways.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.