Bone marrow mesenchymal stem cells ameliorate hepatic ischemia/reperfusion injuries via inactivation of the MEK/ERK signaling pathway in rats.
RatIschaemia-reperfusionHepaticSprague-DawleySystemic infusion via the tail vein
Model: 70% hepatic ischemia-reperfusion injury
Systemic MSC infusion significantly reduced liver enzyme release and improved histology of the acutely injured liver. MSC conditioned medium promoted hepatocyte proliferation and directly inhibited hydrogen peroxide induced apoptosis, with prevention of MEK/ERK pathway activation identified as pivo…
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