Thrombin activity associated with neuronal damage during acute focal ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntravenous infusionDuring ischemia
Model: Middle cerebral artery occlusion focal cerebral ischemia
Intra-arterial thrombin during ischemia significantly increased vascular disruption and cellular injury and caused cognitive deficit, whereas intravenous argatroban alleviated neurovascular injury and preserved learning and memory. Thrombin proteolytic activity was specifically associated with neur…
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