Multiple anti-inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B-induced lung injury.
MouseChemical/toxinC57BL/6Female100 mg/kgBoth before and after SEB exposure
Model: Staphylococcal enterotoxin B (SEB) induced acute lung inflammation, 50 microg per mouse administered intranasally
Pretreatment and post-treatment with resveratrol significantly reduced SEB-induced pulmonary vascular permeability and inflammation, reduced lung infiltrating cells and attenuated the cytokine storm. This correlated with increased caspase-8 dependent apoptosis in SEB activated T cells, upregulation…
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