PRECLINICAL PUBLICATION · 2012

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Short interfering RNA directed against claudin-5

PMID 22617289 ↗2012Reported benefit

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury.

MouseTBIUnspecifiedmale

Model: Focal traumatic brain injury with malignant cerebral oedema in mice

Temporary size-selective modulation of the blood-brain barrier by claudin-5 siRNA reduced brain swelling and improved cognitive outcome in mice with focal cerebral oedema following traumatic brain injury.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.