THERAPY DOSSIER · th-5727a52010cc

Short interfering RNA directed against claudin-5

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22617289 ↗2012Reported benefit

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury.

MouseTBIUnspecifiedmale

Model: Focal traumatic brain injury with malignant cerebral oedema in mice

Temporary size-selective modulation of the blood-brain barrier by claudin-5 siRNA reduced brain swelling and improved cognitive outcome in mice with focal cerebral oedema following traumatic brain injury.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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