Caloric restriction suppresses microglial activation and prevents neuroapoptosis following cortical injury in rats.
RatTBIPenetrating / ballisticWistarmalen = 80 rats total, 40 ad libitum and 40 calorie restricted, all…Dietary (oral)50% of the average daily food intake of ad libitum fed cont…Started 3 months before cortical stab injury and maintained throughout the reco…
Model: Cortical stab injury to the left somatosensory cortex under Nembutal anaesthesia (50 mg/kg intraperitoneally)
Caloric restriction applied before cortical stab injury kept perilesional microglia largely ramified (activated cells below 15% of the population versus over 80% at 2 days in ad libitum fed rats), abolished detectable induction of soluble TNF-alpha and active caspase-3, and prevented the appearance…
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