THERAPY DOSSIER · th-d1b29450dadd

Caloric restriction

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01109199 ↗PHASE3completed

High-viscosity dietary fibre supplementation of a low-calorie diet on appetite and body weight

Appetite Suppression · Weight Loss

Enrolment: 20 · Results not recorded

NCT02193295 ↗NArecruiting

Reversal of lipid-induced insulin resistance (caloric restriction intervention)

Insulin Resistance · NAFLD

Enrolment: 250 · Results not recorded

NCT01678885 ↗NAcompleted

Assessment of energy balance (low-calorie diet, doubly labelled water)

Caloric Intake and Energy Metabolism

Enrolment: 87 · Results not recorded

NCT03776552 ↗NAactive not recruiting

Gradual versus rapid weight loss including a low energy diet, 1-year weight loss in obesity (GoLow)

Obesity

Enrolment: 293 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22615943 ↗2012Reported benefit

Caloric restriction suppresses microglial activation and prevents neuroapoptosis following cortical injury in rats.

RatTBIPenetrating / ballisticWistarmalen = 80 rats total, 40 ad libitum and 40 calorie restricted, all…Dietary (oral)50% of the average daily food intake of ad libitum fed cont…Started 3 months before cortical stab injury and maintained throughout the reco…

Model: Cortical stab injury to the left somatosensory cortex under Nembutal anaesthesia (50 mg/kg intraperitoneally)

Caloric restriction applied before cortical stab injury kept perilesional microglia largely ramified (activated cells below 15% of the population versus over 80% at 2 days in ad libitum fed rats), abolished detectable induction of soluble TNF-alpha and active caspase-3, and prevented the appearance…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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