Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
RatOtherWistarmaleIntravenous0.2, 1 and 5 mg/kg100 min after the initiation of heatstroke
Model: Heatstroke induced by exposing anaesthetised rats to heat stress at 36 degrees C for 100 min, followed by recovery at 26 degrees C, causing acute lung inflammation and injury
Melatonin at 1 and 5 mg/kg prolonged survival time to 117 and 186 min compared with 59 min in vehicle treated rats, attenuated hyperthermia and hypotension, reduced lung oedema, neutrophil infiltration and haemorrhage, lowered TNF-alpha, IL-1 beta and IL-6 while raising IL-10, and reduced bronchoal…
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