Neurotrophin therapy improves recovery of the neuromuscular continence mechanism following simulated birth injury in rats.
RatCrushPeripheral-nerve crushSprague-Dawleyfemalen = 93 rats total: 32 injured with BDNF treatment, 31 injured w…Local continuous infusion via subcutaneous miniature osmotic pump with a vinyl catheter placed at the pudendal nerve injury site2 micrograms per day delivered locally (1 mg BDNF in 6 mL o…Started immediately after injury
Model: Simulated childbirth injury combining 4 h vaginal distension with a water filled de-tipped Foley catheter and bilateral pudendal nerve crush (two consecutive 30 s crushes with a Castro-Viejo needle holder); sham injury was pudendal nerve isolation alone
Leak point pressure was significantly reduced with saline placebo at 2 weeks compared with both sham injury and BDNF treatment, and resting and leak point external urethral sphincter electromyography amplitude and firing rate were significantly reduced with saline but not with BDNF. Histology showe…
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