OTO-413 single intratympanic injection in subjects with speech-in-noise hearing impairment
Sensorineural Hearing Loss
Enrolment: 110 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sensorineural Hearing Loss
Enrolment: 110 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Simulated childbirth injury combining 4 h vaginal distension with a water filled de-tipped Foley catheter and bilateral pudendal nerve crush (two consecutive 30 s crushes with a Castro-Viejo needle holder); sham injury was pudendal nerve isolation alone
Leak point pressure was significantly reduced with saline placebo at 2 weeks compared with both sham injury and BDNF treatment, and resting and leak point external urethral sphincter electromyography amplitude and firing rate were significantly reduced with saline but not with BDNF. Histology showe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.