Neurotrophin expression in neural stem cells grafted acutely to transected spinal cord of adult rats linked to functional improvement.
RatSpinal cord injuryComplete transectionSprague-DawleyIntraspinal transplantation into the lesionAcutely at the time of transection
Model: Spinal cord transection
Neural stem cell transplantation significantly improved hindlimb locomotor function. Only BDNF and NT-3 mRNA, not NGF, were markedly upregulated in the injured segment, with simultaneous downregulation of caspase-3. Little corticospinal tract regeneration was seen.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.