The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury.
MouseOtherC57BL/6MaleBefore and during mechanical ventilation
Model: High tidal volume mechanical ventilation-induced lung injury
High tidal volume ventilation induced lung injury and induced cyclooxygenase-2 expression and activity in lung and systemically, localised to monocytes and macrophages. Pharmacological cyclooxygenase-2 inhibition with CAY10404 significantly decreased cyclooxygenase activity and attenuated barrier d…
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