THERAPY DOSSIER · th-7eacd3fdecb2

CAY10404 (3-(4-methylsulphonylphenyl)-4-phenyl-5-trifluoromethylisoxazole)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02850211 ↗PHASE4completed

A Selective COX-2 Inhibitor (Celecoxib) After Arthroscopic Rotator Cuff Repair

Rotator Cuff Tear

Enrolment: 180 · Results not recorded

NCT00050362 ↗PHASE2completed

Bupivacaine and a Selective COX-2 Inhibitor (Rofecoxib) in Suppression of Central Sensitization

Pain · Tooth Extraction

Enrolment: 136 · Results not recorded

NCT02711579 ↗PHASE1completed

Selective COX-2 Inhibitor Celecoxib on Cortical Excitability in Healthy Volunteers

Electrophysiologic Property of Brain

Enrolment: 40 · Results not recorded

NCT02413203 ↗NAcompleted

Pharmacological Response to Celecoxib Using ex Vivo Human Whole-blood Assay and Lipidomics

Healthy

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22556158 ↗2012Reported benefit

The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury.

MouseOtherC57BL/6MaleBefore and during mechanical ventilation

Model: High tidal volume mechanical ventilation-induced lung injury

High tidal volume ventilation induced lung injury and induced cyclooxygenase-2 expression and activity in lung and systemically, localised to monocytes and macrophages. Pharmacological cyclooxygenase-2 inhibition with CAY10404 significantly decreased cyclooxygenase activity and attenuated barrier d…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

Loading the evidence…