Acute leptin treatment enhances functional recovery after spinal cord injury.
RatSpinal cord injuryUnspecifiedWistarMaleIntraparenchymal injectionAcute, single injection after injury
Model: Spinal cord injury in a clinically relevant animal model
Leptin increased neuroprotective gene expression, reduced caspase-3 activity and pro-inflammatory molecules, reduced microglial reactivity and increased caudal myelin preservation, improving sensory and locomotor recovery. Astroglial reactivity was not modulated.
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