THERAPY DOSSIER · th-7dae7331c3c2

Leptin

Hormone · Recombinant N-methionyl human leptin analogue; direct agonist at the leptin receptor (CHEMBL5913); ATC A16AA07; orphan designation; black box warning TRUE. Native leptin itself is not a separate ChEMBL drug entity; metreleptin recorded as the closest indexed entity

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Recombinant N-methionyl human leptin analogue; direct agonist at the leptin receptor (CHEMBL5913); ATC A16AA07; orphan designation; black box warning TRUE. Native leptin itself is not a separate ChEMBL drug entity; metreleptin recorded as the closest indexed entity
Target: CHEMBL5913 (leptin receptor)
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 2014
Development stage: Not recorded
ChEMBL record: CHEMBL2107857 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Leptin (human), n-methionyl-; Metreleptin; Myalept; Myalepta; N-methionylleptin (human); R-METHULEPTIN
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05164341 ↗PHASE3active not recruiting

Daily Subcutaneous Metreleptin in Subjects With Partial Lipodystrophy

Partial Lipodystrophy

Enrolment: 69 · Results not recorded

NCT00265980 ↗NAterminated

Leptin in Human Energy and Neuroendocrine Homeostasis

Obesity · Weight Loss

Enrolment: 22 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22536415 ↗2012Reported benefit

Acute leptin treatment enhances functional recovery after spinal cord injury.

RatSpinal cord injuryUnspecifiedWistarMaleIntraparenchymal injectionAcute, single injection after injury

Model: Spinal cord injury in a clinically relevant animal model

Leptin increased neuroprotective gene expression, reduced caspase-3 activity and pro-inflammatory molecules, reduced microglial reactivity and increased caudal myelin preservation, improving sensory and locomotor recovery. Astroglial reactivity was not modulated.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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