Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleInhaled, hyperbaric chamber100% oxygen at 2.0 absolute atmospheresBeginning after traumatic brain injury onset, for three consecutive days
Model: Traumatic brain injury
Hyperbaric oxygen significantly reduced motor and cognitive dysfunction, cerebral infarction and apoptosis, inflammation, neuronal loss and gliosis, while stimulating angiogenesis, neurogenesis and interleukin-10 overproduction at 4 days after injury.
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