Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.
MouseHaemorrhage/shockUnspecifiedCD-1Malen = 179 mice in total; study 1 groups of 4 to 22, study 2 group…Inhalational2% isoflurane with 30% oxygen and 70% medical airPost-treatment starting 1 hour after subarachnoid haemorrhage induction
Model: Subarachnoid haemorrhage by endovascular perforation of the anterior cerebral artery, with early brain injury
Isoflurane significantly improved neurobehavioural function and brain water content at 24 hours but not at 72 hours. It attenuated cortical neuronal cell death, increased sphingosine kinase 1 and phosphorylated Akt and decreased cleaved caspase-3. These effects were abolished by the sphingosine kin…
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