Gabapentin inhibits gamma-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
RatOtherSprague-DawleyMalen = 12 to 13 rats per microdialysis group; 5 to 6 per group for…Intravenous via jugular vein for microdialysis studies; bath application for synaptosomesGabapentin 10 and 50 mg/kg intravenously; pregabalin 30 mg/…Seven to ten days after spinal nerve ligation
Model: L5-L6 spinal nerve ligation
Gabapentin dose-dependently decreased locus coeruleus GABA concentrations in normal rats, and only the 50 mg/kg dose did so in nerve-ligated rats, with a greater absolute decrease in ligated rats. In the spinal dorsal horn gabapentin had no effect in normal rats and slightly increased GABA in ligat…
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