TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.
MouseTBIUnspecifiedC57BL/6n = 6 mice for histology, 12 for behavioural testing, 3 per gro…Administered following injury and then for four subsequent days
Model: Murine traumatic brain injury and intracerebral haemorrhage
TT-301 reduced F4/80 staining at 1 and 10 days but not 28 days, improved Rotorod performance by 52.7% at day 7 and Morris water maze latencies by 232.5% after traumatic brain injury, and after intracerebral haemorrhage improved Rotorod performance by 39.6% and reduced cerebral oedema independently…
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