THERAPY DOSSIER · th-9fce005e3e30

TT-301

Drug · No ChEMBL MoA record; suppressor of pro-inflammatory cytokine production (p38 MAPK pathway); anti-neuroinflammatory

Not approved Suggest a correction

Evidence & regulatory context

Mechanism: No ChEMBL MoA record; suppressor of pro-inflammatory cytokine production (p38 MAPK pathway); anti-neuroinflammatory
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4297448 ↗
ChEMBL max phase: 1 / 4 (development scale, not regulatory approval)
Synonyms: TT-301; TT301; MW-189; MW01-6-189WH
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05020535 ↗Injury indicationPHASE2active not recruiting

Biomarker and Edema Attenuation in Intracerebral Hemorrhage (BEACH) - MW189

Intracerebral Hemorrhage

Enrolment: 120 · Results not recorded

NCT01357421 ↗Injury indicationPHASE1completed

Single IV Dose of TT301 on LPS-induced Changes in Blood Cytokine Levels in Healthy Volunteers

Traumatic Brain Injury

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22487803 ↗2012Reported benefit

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

MouseTBIUnspecifiedC57BL/6n = 6 mice for histology, 12 for behavioural testing, 3 per gro…Administered following injury and then for four subsequent days

Model: Murine traumatic brain injury and intracerebral haemorrhage

TT-301 reduced F4/80 staining at 1 and 10 days but not 28 days, improved Rotorod performance by 52.7% at day 7 and Morris water maze latencies by 232.5% after traumatic brain injury, and after intracerebral haemorrhage improved Rotorod performance by 39.6% and reduced cerebral oedema independently…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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