Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
RatEndotoxin/LPSSprague-DawleyMaleIntraperitonealSivelestat sodium 10 mg/kg; edaravone 8 mg/kg1 h after LPS instillation
Model: Intratracheal instillation of lipopolysaccharide 2 mg/kg to induce acute lung injury
Sivelestat or edaravone alone reduced neutrophil infiltration, histological injury and pro-inflammatory cytokines, while only edaravone lowered malondialdehyde. The combination gave additive protection relative to either single agent.
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