Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection.

Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection.

Model: T10 laminectomy followed by impact contusion of the spinal cord

Rapamycin improved Basso, Beattie and Bresnahan scores by day 28, increased LC3-II and reduced p70S6K phosphorylation consistent with autophagy promotion. It also lowered tumour necrosis factor production and microglial activation and preserved NeuN-positive neurons.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.