Non-endothelial cell endothelin-B receptors limit neointima formation following vascular injury.
MouseOtherC57BL/6, including mice with endothelium-specific endothelin-B receptor deletionMale
Model: Wire injury or ligation injury of the femoral artery inducing neointimal proliferation
Endothelin-A receptor blockade reduced lesion burden in both injury models, whereas endothelin-B blockade increased lesion burden after wire injury to 184 per cent of vehicle and reversed the benefit of endothelin-A antagonism. Endothelium-specific endothelin-B deletion had no effect, indicating th…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.