Docetaxel + atrasentan vs docetaxel + placebo in HRPC
Metastatic Cancer · Prostate Cancer
Enrolment: 1038 · Results not recorded
Loading the evidence…
Drug · ANTAGONIST at endothelin receptor ET-A (direct interaction, disease efficacy); USAN stem -entan (endothelin receptor antagonists).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Metastatic Cancer · Prostate Cancer
Enrolment: 1038 · Results not recorded
Prostate Cancer
Enrolment: 1000 · Results not recorded
Diabetic Nephropathy
Enrolment: 5107 · Results not recorded
Prostate Cancer · Adenocarcinoma of the Prostate
Enrolment: 44 · Results not recorded
Chronic Kidney Disease · Diabetic Nephropathy
Enrolment: 149 · Results not recorded
Chronic Kidney Disease · Diabetic Nephropathy
Enrolment: 58 · Results not recorded
IgA Nephropathy · Focal Segmental Glomerulosclerosis · Alport Syndrome · Diabetic Kidney Disease
Enrolment: 103 · Results not recorded
Fallopian Tube Cancer · Ovarian Cancer · Peritoneal Cavity Cancer
Enrolment: 15 · Results not recorded
Brain and Central Nervous System Tumors
Enrolment not recorded · Results not recorded
IgA Nephropathy
Enrolment: 80 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Neonatal hypoxic-ischaemic brain injury (Rice-Vannucci: carotid ligation + 8% oxygen 2 h)
ETA receptor blockade with ABT-627 had no effect on brain oedema, infarct volume or neurological outcomes after neonatal hypoxic-ischaemic injury in rats.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Wire injury or ligation injury of the femoral artery inducing neointimal proliferation
Endothelin-A receptor blockade reduced lesion burden in both injury models, whereas endothelin-B blockade increased lesion burden after wire injury to 184 per cent of vehicle and reversed the benefit of endothelin-A antagonism. Endothelium-specific endothelin-B deletion had no effect, indicating th…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.