Inhibition of hypoxia inducible factor-1alpha ameliorates lung injury induced by trauma and hemorrhagic shock in rats.
RatHaemorrhage/shockUnspecifiedWistarMaleIntratracheal1 mg/kg
Model: Laparotomy plus haemorrhagic shock for 60 min followed by resuscitation for 3 h
Intratracheal YC-1 significantly attenuated trauma and haemorrhagic shock induced lung injury and reduced pulmonary HIF-1alpha and iNOS expression together with HIF-1alpha transcriptional activity. Local HIF-1alpha inhibition therefore alleviates this form of acute lung injury.
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