THERAPY DOSSIER · th-3a6eb007cbba

YC-1

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03217591 ↗PHASE2completed

IW-1973 (praliciguat) in type 2 diabetes with albuminuria

Type 2 Diabetes Mellitus With Diabetic Nephropathy

Enrolment: 156 · Results not recorded

NCT02792998 ↗PHASE1completed

IW-1701 (olinciguat) multiple ascending dose in healthy subjects

Healthy

Enrolment: 67 · Results not recorded

NCT02572349 ↗PHASE1completed

IW-1701 (olinciguat) single ascending dose in healthy subjects

Healthy

Enrolment: 24 · Results not recorded

NCT05582811 ↗NAcompleted

Riociguat, sGC stimulator: cerebral vasodilation and headache induction in healthy volunteers

Headache

Enrolment: 15 · Results not recorded

NCT02428985 ↗NAcompleted

Drug use investigation of riociguat for pulmonary arterial hypertension

Hypertension, Pulmonary

Enrolment: 882 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22465950 ↗2012Reported benefit

Inhibition of hypoxia inducible factor-1alpha ameliorates lung injury induced by trauma and hemorrhagic shock in rats.

RatHaemorrhage/shockUnspecifiedWistarMaleIntratracheal1 mg/kg

Model: Laparotomy plus haemorrhagic shock for 60 min followed by resuscitation for 3 h

Intratracheal YC-1 significantly attenuated trauma and haemorrhagic shock induced lung injury and reduced pulmonary HIF-1alpha and iNOS expression together with HIF-1alpha transcriptional activity. Local HIF-1alpha inhibition therefore alleviates this form of acute lung injury.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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