Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.
RatTBIControlled cortical impactHarlan Sprague-DawleyMalen = 64 rats in total; four injured groups of n=10 to 12 and fou…Intraperitoneal8-OH-DPAT 0.5 mg/kg; WAY 100635 0.5 mg/kg; SB 269970 HCl 2.…8-OH-DPAT 15 min after injury; antagonists immediately before injury, that is 1…
Model: Controlled cortical impact to the exposed right cortex, 2.8 mm depth at 4 m/s, under isoflurane anaesthesia after craniectomy; shams underwent identical surgery without impact
8-OH-DPAT alone, and combined with WAY 100635, improved Morris water maze acquisition relative to vehicle, and 8-OH-DPAT alone improved probe retention at 35.1 plus or minus 1.1 per cent versus 24.6 plus or minus 2.6 per cent. Co-administration with the 5-HT7 antagonist SB 269970 HCl abolished the…
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