Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury.
RatChemical/toxinWistarMale50 mg/kg1 h before and 1 h after induction of acute pancreatitis
Model: Mild acute pancreatitis by bile-pancreatic duct obstruction and severe acute pancreatitis by infusion of 3.5 per cent sodium taurocholate into the bile-pancreatic duct
N-acetylcysteine reduced hyperamylasaemia in both models and downregulated MCP-1, CINC and P-selectin in duct obstruction pancreatitis, but not in the taurocholate model. It did not prevent leukocyte infiltration and aggravated lung damage in severe pancreatitis while giving no benefit in the mild…
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