Lithium pretreatment reduces brain injury after intracerebral hemorrhage in rats.
RatOtherSprague-DawleyMale2 mEq/kgPretreatment for 3 days before induction of intracerebral haemorrhage
Model: Stereotaxic infusion of collagenase into the left basal ganglia to induce intracerebral haemorrhage
Lithium pretreatment improved behavioural recovery at 2 days and reduced hemispheric swelling at 3 days and hemispheric atrophy at 42 days, without altering hematoma volume. Perihaematomal cell death, cyclooxygenase-2 expression and reactive microglia were all reduced.
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