Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain.
RatSpinal cord injuryCompressionSprague-DawleyMaleIntrathecal via lumbar catheter, 5 microL followed by a 5 microL vehicle flushMuscimol 0.1 to 3 microg; baclofen 0.1 to 1 microg; ketamin…Treatment 4 weeks after spinal compression, in established chronic neuropathic…
Model: Acute thoracic spinal cord compression under isoflurane, with a microvascular clip placed vertically over the exposed cord for 60 s after laminectomy with dura intact; lumbar intrathecal catheter implanted 3 weeks later
Intrathecal muscimol and baclofen each produced dose-dependent antinociception with peak effects of 58.5 and 85.9 per cent maximum possible effect, whereas ketamine and [Ser1]histogranin were ineffective alone. Only baclofen plus ketamine was synergistic and this was fully blocked by CGP 35348 pret…
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