Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 76 rats in total; mitochondrial arm n=8 per group; long-ter…Intraperitoneal300 mg/kg, dissolved at 300 mg/mL and injected at 1 microL/…First dose 15 min after contusion, booster at 6 h
Model: Contusion spinal cord injury with the Infinite Horizon impactor under ketamine 80 mg/kg and xylazine 10 mg/kg anaesthesia; dorsal laminectomy at T10 exposing T9/T10 (n=12) or at T12 exposing L1/L2 (n=64), with contusions of 200 kdyn for T10 and 250 kdyn for L1/L2; shams received laminectomy only
Acetyl-L-carnitine preserved the mitochondrial respiratory control ratio and complex I driven respiration at 24 h and, after L1/L2 contusion, produced consistent weight-supported plantar stepping with greater grey and white matter sparing and more ChAT-positive lamina X neurons rostral to the epice…
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