Neuroprotective effects of racemic ketamine and (S)-ketamine on spinal cord injury in rat.
RatSpinal cord injuryCompressionWistar albinoMalen = 59 ratsIntraperitonealRacemic ketamine 60 mg/kg; (S)-ketamine 60 mg/kg; methylpre…4 h after clip compression
Model: Dorsal laminectomy followed by spinal cord injury induced with a temporary aneurysm clip
All three drugs reduced lipid peroxidation in the acute stage, but only (S)-ketamine did so significantly in the subacute stage, making it more effective than racemic ketamine or methylprednisolone for this endpoint. Histopathological protection with (S)-ketamine was comparable to methylprednisolon…
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