PRECLINICAL PUBLICATION · 2012

Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Ibudilast

PMID 22435644 ↗2012Reported benefit

Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury.

RatTBIFluid percussionSprague-DawleyMaleAcute peri-injury administration

Model: Lateral fluid percussion injury

Peri-injury ibudilast suppressed reactive gliosis and anxiety-like freezing behaviour, with neuroprotective effects persisting several months after injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.