Phase 2b/3 Trial of MN-166 (Ibudilast) With Open-Label Extension in Subjects With ALS
Amyotrophic Lateral Sclerosis
Enrolment: 234 · Results not recorded
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Drug · Non-selective phosphodiesterase inhibitor: PDE4, PDE3A, PDE10A and PDE5A inhibitor (INHIBITOR; direct interaction); also active against PDE11
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Amyotrophic Lateral Sclerosis
Enrolment: 234 · Results not recorded
Long COVID · Post COVID Condition
Enrolment: 460 · Results not recorded
Alcohol Use Disorder
Enrolment: 102 · Results not recorded
Pneumonia, Viral
Enrolment: 34 · Results not recorded
Methamphetamine-dependence
Enrolment: 176 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 35 · Results not recorded
Migraine Headache
Enrolment: 33 · Results not recorded
Alcohol Use Disorders
Enrolment: 24 · Results not recorded
Healthy Volunteers
Enrolment: 12 · Results not recorded
ALS
Enrolment not recorded · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Lateral fluid percussion traumatic brain injury in rats
Delayed anti-inflammatory treatment starting 1 month after lateral fluid percussion injury substantially reduced established freezing behaviour and reactive gliosis, with continued neuroprotective effects 6 months after treatment.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Partial sciatic nerve injury (modified chronic constriction injury, N1S3 configuration, single chromic gut suture loosely tied at mid-thigh) combined with repeated intraperitoneal codeine or morphine exposure
Repeated codeine produced hyperalgesia and allodynia comparable to equimolar morphine despite less acute analgesia, while IL-1RA reversed both, TLR4 knockout was protective and ibudilast reversed established allodynia.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Mid-thoracic spinal cord injury (clip) and sciatic chronic constriction injury
Ibudilast ameliorated tactile hypersensitivity in both central spinal cord injury and peripheral neuropathic pain models.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Lateral fluid percussion injury
Peri-injury ibudilast suppressed reactive gliosis and anxiety-like freezing behaviour, with neuroprotective effects persisting several months after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.