Granulocyte colony stimulating factor prevents kidney infarction and attenuates renovascular hypertension.
MouseIschaemia-reperfusionRenalC57BL/6Malen = n=8 per group for arterial pressure100 microgram/kg/dayStarted after renal artery clipping or sham operation
Model: Two-kidney one-clip (2K1C) left renal artery clipping causing renal ischaemia and infarction
G-CSF lowered arterial pressure (129 vs 150 mmHg), prevented the rise in plasma angiotensins, reduced ischaemic kidney atrophy and prevented infarction in 7 of 8 mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.