Th2 cytokine-mediated methimazole-induced acute liver injury in mice.
MouseChemical/toxinBALB/cFemaleIntraperitoneal100 microgram per mouse
Model: Methimazole-induced acute liver injury (methimazole 450 mg/kg orally; sensitised model using L-buthionine sulfoximine 3 mmol/kg intraperitoneally plus methimazole 15 mg/kg orally)
Neutralising interleukin-4 suppressed the hepatotoxic effect of methimazole, supporting a Th2 cytokine-mediated mechanism of injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.