Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils
Allergy
Enrolment: 25 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Allergy
Enrolment: 25 · Results not recorded
Allergic Rhinitis, Seasonal
Enrolment: 150 · Results not recorded
Dermatitis, Atopic
Enrolment: 180 · Results not recorded
Dermatitis, Atopic
Enrolment: 128 · Results not recorded
Chronic Spontaneous Urticaria · Hidradenitis Suppurativa · Psoriasis · Atopic Dermatitis · CTCL/Mycosis Fungoides
Enrolment: 840 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Methimazole-induced acute liver injury (methimazole 450 mg/kg orally; sensitised model using L-buthionine sulfoximine 3 mmol/kg intraperitoneally plus methimazole 15 mg/kg orally)
Neutralising interleukin-4 suppressed the hepatotoxic effect of methimazole, supporting a Th2 cytokine-mediated mechanism of injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.