Systemic involvement of high-mobility group box 1 protein and therapeutic effect of anti-high-mobility group box 1 protein antibody in a rat model of crush injury.
RatCrushLimb / muscle crushWistarMalen = n=20 per group for survival; n=6-9 per group for other endp…IntravenousAfter release of compression
Model: Bilateral hindlimb compression for 6 h followed by release (crush injury)
Anti-HMGB1 antibody improved survival, suppressed serum HMGB1, interleukin-6 and tumour necrosis factor alpha, and reduced lung damage and RAGE expression.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.