Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion.
RatIschaemia-reperfusionIntestinal / mesentericWistar albinoMalen = 10 animals per group, 30 rats totalIntravenous3 mg/kg3 days before ischaemia/reperfusion
Model: Intestinal ischaemia/reperfusion by 1 h superior mesenteric artery ligation followed by 1 h reperfusion, causing acute lung injury
Infliximab pre-treatment lowered lung malondialdehyde, raised antioxidant enzyme activity, reduced histological lung injury and inducible nitric oxide synthase, and increased surfactant protein D.
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