Role of mesenchymal stem cells on cornea wound healing induced by acute alkali burn.
RatBurnChemical / corrosiveSprague-Dawley (mesenchymal stem cell donors were two-week-old female Sprague-Dawley rats)Femalen = 48 rats total, 24 per group; 8 rats per group for staining…Subconjunctival injection2 x 10^6 DiI-labelled mesenchymal stem cells in 0.1 mL phos…Immediately after the burn (day 0) and again on day 3
Model: Corneal alkali burn using a 3 mm filter paper soaked in sodium hydroxide applied to the right eye
Subconjunctival mesenchymal stem cells accelerated corneal epithelial recovery, reduced neovascularisation and CD68-positive infiltration, and lowered MIP-1 alpha, tumour necrosis factor alpha and VEGF; MCP-1 was unchanged.
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