Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats.
RatSpinal cord injuryContusionWistarFemaleLow dose 0.5 mg/kg and higher dose 1 mg/kg; methylprednisol…
Model: Spinal cord injury by 50 g/cm weight drop trauma
Methotrexate significantly reduced myeloperoxidase activity and malondialdehyde level in the first 24 h and was more effective than methylprednisolone; it better preserved large and medium diameter myelinated axons and produced no neurotoxicity in uninjured cord.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.