Hyperbaric oxygen therapy attenuates neuropathic hyperalgesia in rats and idiopathic trigeminal neuralgia in patients.
RatOtherSprague-DawleyMale (rats)Hyperbaric chamber exposure3 atmospheres absolute with pure oxygen
Model: Sciatic nerve injury producing neuropathic pain in rats; clinical arm in patients with idiopathic trigeminal neuralgia
Repetitive hyperbaric oxygen greatly inhibited thermal hyperalgesia and mechanical allodynia and the associated neurochemical changes in rats, and produced rapid-onset, dose-dependent and long-lasting analgesia in patients with idiopathic trigeminal neuralgia.
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