CPSI-121 pharmacologically prevents intestinal barrier dysfunction after cutaneous burn through a vagus nerve-dependent mechanism.
MouseBurnUnspecifiedBALB/c (Jackson Laboratories)MaleIntravenous tail vein injection1 mg/kg diluted in 150 microlitre sterile water; vagus nerv…Immediately after the burn, with assessment at 4 hours
Model: Full-thickness 30% total body surface area dorsal steam burn applied for 7 seconds under inhaled isoflurane, with subcutaneous saline and buprenorphine resuscitation
CPSI-121 significantly reduced 4-kDa FITC-dextran permeability and preserved normal ileal histology and ZO-1 and occludin expression after burn, comparably to vagus nerve stimulation; abdominal vagotomy abolished the protection while splenectomy did not.
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