Ligustrazine attenuates acute lung injury induced by blunt chest trauma.
RatOtherSprague-DawleyMalen = n = 60 per group across four groupsIntraperitoneal injection
Model: Blunt chest trauma producing lung contusion
Ligustrazine significantly reduced apoptosis index and pulmonary oedema (p = 0.04), lowered plasma TNF-alpha (p = 0.03) and caspase-3 expression (p = 0.03) and raised the Bcl-2 to Bax ratio (p < 0.03) after blunt chest trauma.
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